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International Journal of Clinical Research. 2019; 3: (1) 6; DOI: 10.26855/j.ijcr.20190006.

Research Progress of the Relationship Between Ovarian Cancers and Mitochondria
卵巢癌與線粒體關系的研究進展

作者: 李歡妮,周田,曹蘭琴,詹顯全*

*通訊作者:詹顯全,單位:中南大學湘雅醫院;

引用本文: 李歡妮,周田,曹蘭琴,詹顯全. 卵巢癌與線粒體關系的研究進展[J]. 國際臨床研究雜志, 2019, 3(1) : 26-32.
Published: 2019-09-16

摘要

促性腺激素假說和二元論假說促進了人們對卵巢癌發病機制的認識,然而其分子病理機制仍不清楚,障礙了卵巢癌的早期診斷、治療和預后評估。線粒體作為細胞能量代謝、氧化應激和細胞信號的中心,與卵巢癌的發生、發展、治療和預后有著密切的關系。隨著線粒體蛋白質組學的發展,線粒體的分離和純化,及其蛋白質的檢測、鑒定和定量均有極大改善,有利于全面深入研究卵巢癌線粒體及其功能機制,發現以線粒體為靶點的分子標志物、藥物靶點,服務于卵巢癌的早期診斷和治療,改善其預后。

關鍵詞: 卵巢癌,線粒體,機制,蛋白質組,蛋白質組學,分子標志物,藥物靶點

Abstract

The gonadotropin hypothesis and the dualism hypothesis have promoted people's understanding of the pathogenesis of ovarian cancer. However, its molecular pathological mechanism remains unclear so that hinders the early-stage diagnosis, treatment and prognostic assessment of ovarian cancer. Mitochondria, as the centers of cellular energy metabolism, oxidative stress, and cell signaling, are closely related to the occurrence, development, treatment and prognosis of ovarian cancers. With the development of mitochondrial proteomics, the isolation and purification of mitochondria, as well as the detection, identification, and quantification of proteins have been significantly improved, which are conducive to a comprehensive and in-depth study of mitochondria of ovarian cancers and its functional mechanisms, further discovering molecular biomarkers and therapeutic targets targeting mitochondria, and contributing to the early diagnosis and treatment of ovarian cancer and improving its prognosis.

Key words: Ovarian cancer, Mitochondria, Mechanism, Proteome, Proteomics,Molecular biomarker, Therapeutic target

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